VET 405: Gastrointestinal/Metabolism

Comparative GI Anatomy, Ruminant Digestion, GI Physiology & Metabolic Diseases

VET 405: GASTROINTESTINAL SYSTEM & METABOLISM MODULE 1: COMPARATIVE GI ANATOMY - Oral cavity: tooth anatomy (incisors, canines, premolars, molars), species variation, eruption times - Esophagus: muscular tube, species differences in innervation - Stomach: monogastric (carnivores, horses, pigs) vs ruminant forestomach - Canine/feline stomach: simple pouch, gastric glands (parietal, chief, mucus-secreting) - Equine stomach: small relative to body size, continuous gastric secretion - Small intestine: duodenum (pancreatic/bile duct entry), jejunum, ileum; intestinal villi structure - Colon/cecum: water absorption, fiber fermentation, species variation - Ruminant GI: esophageal grooves, 4-chambered forestomach (rumen, reticulum, omasum, abomasum) MODULE 2: RUMINANT FORESTOMACH ANATOMY & PHYSIOLOGY - Rumen: fermentation vat (45-50 L in cattle), anaerobic fermentation by microbes - Ruminant microbiota: bacteria (Firmicutes, Bacteroidetes), archaea (methanogens), ciliate protozoa - Fermentation pathways: cellulose → volatile fatty acids (acetate, propionate, butyrate) - Ruminant: cud chewing, salivary buffering (maintains pH 6-7), eructation (belching) - Omasum: water absorption, particle sorting - Abomasum: true stomach, gastric secretion (HCl, pepsin, renin in neonates) - Ruminant intestinal anatomy: longer small intestine for microbial byproduct absorption MODULE 3: GI PHYSIOLOGY & DIGESTION - Saliva: amylase (minimal in carnivores), mucus lubrication, buffering; salivary glands (parotid, submandibular) - Gastric secretion: parietal cells (HCl, intrinsic factor), chief cells (pepsinogen), G cells (gastrin) - Gastric motility: fundic relaxation, antral grinding, pyloric sphincter control - Pancreatic secretion: bicarbonate (buffer stomach acid), digestive enzymes (amylase, lipase, proteases) - Bile: produced by liver, stored in gallbladder (except horses, no storage); emulsifies fats - Small intestinal digestion: brush border enzymes (peptidases, disaccharidases), nutrient absorption - Colonic function: water resorption, bacterial fermentation (fiber), short-chain fatty acid production MODULE 4: METABOLIC DISORDERS - Ketosis (acetonemia): excessive fat mobilization, inadequate carbohydrate intake - Hypoglycemia: decreased blood glucose; causes (starvation, sepsis, liver disease, excessive insulin) - Hyperglycemia: elevated glucose; causes (diabetes mellitus, stress, corticosteroids) - Electrolyte imbalances: hypokalemia, hyponatremia, hypocalcemia (milk fever), hyperkalemia - Hepatic lipidosis: fatty liver from lipid accumulation, common in obese/anorectic cats - Protein-energy malnutrition: inadequate amino acids/calories, muscle catabolism, poor wound healing MODULE 5: COLIC & GI EMERGENCIES - Colic (equine): abdominal pain from GI disorder; types include impaction, displacement, torsion, strangulation - Acute abdomen signs: severe pain, dark mucous membranes, prolonged capillary refill, shock - Surgical vs medical colic: impaction (medical), large colon displacement (surgical), torsion (surgical) - Peritonitis: abdominal inflammation from perforation/infection; diffuse pain, systemic toxemia - GI foreign bodies: obstruction from non-digestible items; radiographic diagnosis, endoscopy or surgery